Free 15 Minute Consultation | Get Directions | (480) 741-2200

“Dr Dan Wool” logo with teal circular emblem with white line drawing saguaro cactus with two arms and text “Naturopathic Gastroenterologist” on black background.
“Dr Dan Wool” logo with teal circular emblem with white line drawing saguaro cactus with two arms and text “Naturopathic Gastroenterologist” on black background.
Specialties
My Approach
Pricing
FAQ
Testimonials
Articles
Podcast
Videos
Contact
Patient Login
BOOK NOW
Dr. Wool's Natural Gastro Blog/Bloating/12 min read

Why You're Bloated Every Day and What It's Telling You

By Dr Dan Wool, NMD11/5/2026
A bloated woman laying on top of a bed next to a pillow

Written and Medically Reviewed by Dr. Dan Wool, NMD
Arizona-Licensed Naturopathic Physician and Gastroenterology Specialist
Updated: November 5, 2026

Quick Summary

  • Bloating is a symptom with several possible causes, and most people have more than one running at once. The timing of your bloating, what triggers it, and what shows up alongside it point toward the cause more reliably than any single lab test.

  • Eight patterns cover most of what I see in practice, from bloating within minutes of a meal to bloating that peaks before your period. Each pattern points to a different engine, including bacterial overgrowth, slow motility, histamine overload, hormone shifts, and a muscle reflex.

  • Histamine is one of the most overlooked causes. When histamine from food and gut bacteria outpaces the enzyme that clears it, bloating is often the first and worst symptom, usually with flushing, headaches, or a stuffy nose.

  • Alarm signs need a conventional workup first. After that, I map your pattern, test for the likely driver, treat it, and rebuild. Many patients notice a clear change within four to six weeks, and layered cases take longer.

Lauren (name changed for privacy) is 36 and sells commercial real estate in Tempe.

She wakes up with a flat stomach. By four in the afternoon her work pants won't button, and by dinner she looks six months pregnant.

Her primary care doctor ran a celiac panel and a metabolic panel, and both came back normal. A gastroenterologist did an upper endoscopy, found nothing, and called it IBS.

So Lauren did what motivated patients do.

She cut gluten, started a probiotic, and replaced lunch with a green smoothie and a bottle of kombucha. The bloating got worse.

She also noticed that one glass of wine made her face flush, her nose stuffed up at dinner, and everything peaked the week before her period.

I see some version of Lauren in my Scottsdale practice nearly every week. Normal labs left her without an explanation for symptoms that followed a clear and readable pattern. 

This guide shows you how to read yours.

What Bloating Actually Means

Bloating is the feeling of fullness, pressure, tightness, or trapped gas in your abdomen. It usually comes from one or more of three layers:

  • Gas production: Bacteria ferment food that wasn't fully digested, and gas builds.

  • Gas handling: Slow motility, constipation, or a tight pelvic floor keep gas and stool from moving.

  • Sensation and reflex: A sensitive gut wall registers normal gas as painful, and the abdominal muscles can push the belly outward.

Bloating, Distension, and the Look-Alikes

Bloating is something you feel.

Distension is something you can see and measure.

The American Gastroenterological Association treats them as related but separate problems, and each can show up without the other.[1]

Bloating with a flat belly usually points toward a sensitive gut wall.

Distension you can see in the mirror points toward trapped gas or stool, or toward the abdominal muscle reflex described below.

A simple check helps. For a few days, measure your waist at the navel when you wake up and again before bed. A waist that grows through the day and resets overnight fits functional distension.

Several other problems look like bloating and call for a different plan.

  • Belly fat stays the same size from morning to night.

  • Water retention tends to show up in your ankles, hands, and face as well, often tied to salt intake or your cycle.

  • Diastasis recti is a separation of the abdominal muscles that's common after pregnancy. The belly domes along the midline when you sit up or lift.

  • Fluid in the abdomen or a growing mass doesn't go down overnight. Either one needs prompt medical evaluation.

Why I Read Bloating Like a Map

A label like IBS or functional bloating describes the symptom. It doesn't tell you which engine is driving it.

Three questions narrow the list fast:

  • When does your bloating start?

  • What makes it worse?

  • What shows up with it?

Your answers sort you into one or more of the eight patterns below.

How Bloating Shows Up

In a survey of more than 51,000 adults across 26 countries, nearly 18 percent reported bloating at least once a week. Women were about twice as likely as men to report it.[2]

In the gut, bloating looks like a waistband that tightens as the day goes on, visible distension, gas, early fullness, belching, and a change in bowel habits.

Outside the gut, my patients with chronic bloating often describe fatigue after meals, brain fog, headaches, flushing, skin flares, and a low mood that tracks with their worst bloating days. Those systemic symptoms are clues to the cause, so I ask about every one.

Warning Signs That Need a Conventional Workup First

  • Blood in your stool or black, tarry stools.

  • Unintentional weight loss.

  • Iron deficiency anemia.

  • Symptoms that wake you from sleep.

  • Fever with diarrhea.

  • Trouble swallowing or persistent vomiting.

  • A family history of colon cancer, IBD, or celiac disease.

  • New bowel changes after age 50.

  • A belly that keeps growing week over week or never goes down overnight.

  • New, persistent bloating with early fullness or pelvic pain in women over 50.

Conventional gastroenterology handles these situations well. Imaging and endoscopy are the right tools when alarm features are present, and that step always comes first.[1]

What a Normal Scope and Normal Labs Don't Measure

A scope shows the lining of your esophagus, stomach, and colon. It can't measure how much gas your bacteria produce, where those bacteria live, how fast food moves through your small intestine, how well you clear histamine, or how your diaphragm and abdominal wall react after a meal.

Standard blood work doesn't track your hormones across a cycle either. Those are the places I look next.

How I Test for the Cause of Bloating

I start with a two-week symptom and food diary that tracks timing, meals, bowel movements, stress, workouts, and cycle days. The pattern usually tells me which tests are worth ordering.

  • Breath testing measures the hydrogen and methane your gut bacteria produce after a sugar drink. The North American Consensus considers it useful for evaluating bloating and gas, and it defines methane at or above 10 parts per million as positive.[3] Preparation and transit speed can skew results, so I read them alongside your history.

  • Comprehensive stool analysis shows bacterial balance, inflammation markers, pancreatic enzyme output, and overgrowth of bacteria known to produce histamine.

  • Blood work fills in the rest: celiac serology if it hasn't been done, a full thyroid panel, ferritin, and serum DAO and tryptase when the histamine pattern fits. When bloating follows the cycle, I add hormone testing timed to the right phase. No single test explains bloating. The pattern and the results together do.

8 Bloating Patterns and What Each Points To

1. Bloated within 30 minutes of eating

Fast bloating usually starts in the upper gut. In my practice this pattern often traces back to low stomach acid, weak pancreatic enzyme output, or a stomach that empties slowly, all of which leave food poorly digested before it moves on.

Go deeper: https://www.drdanwool.com/blog/functional-dyspepsia and https://www.drdanwool.com/blog/digestive-enzyme-guide

2. Flat in the morning, distended by evening

Bloating that builds through the day suggests fermentation that stacks up with each meal, which is a common picture in small intestinal bacterial overgrowth (SIBO) and slow motility.

A muscle reflex also plays a role. In abdominophrenic dyssynergia, the diaphragm pushes down while the front abdominal wall relaxes, and the belly juts out. In a randomized trial, biofeedback that retrained this reflex improved the sensation of distension by 56%, compared with 13% on placebo.[4]

Go deeper: https://drdanwool.com/blog/siboguide and https://drdanwool.com/blog/abdominophrenic-dysynergia-chronic-bloating

3. Worse with vegetables, fiber, or "healthy" smoothies

Fermentable carbohydrates (FODMAPs) feed gas-producing bacteria. In a controlled crossover trial, a low-FODMAP diet roughly halved overall symptoms in people with IBS and reduced bloating and gas.[5] Fructose and lactose malabsorption belong in this pattern too.

Go deeper: https://www.drdanwool.com/blog/smoothies-protein-drinks-bloating and https://www.drdanwool.com/blog/low-fodmap-diet

4. Bloating with flushing, headaches, or congestion

This is the histamine pattern. In one study of patients with histamine intolerance, bloating was the most common symptom (reported by 92%) and the most severe.[6] The section below covers how I investigate it.

Go deeper: https://www.drdanwool.com/blog/dao-enzyme-histamine-intolerance

5. Bloating that cycles with your period or hormone changes

In a study of healthy premenopausal women, a majority reported bloating around their period.[7] Shifting estrogen and progesterone change gut motility, fluid balance, and histamine handling, so this pattern often overlaps with patterns 4 and 6.

Go deeper: https://www.drdanwool.com/blog/hormonal-bloating and https://www.drdanwool.com/blog/birthcontrolandbloating

6. Bloating with constipation

Backed-up stool traps gas behind it. A positive methane breath test points toward methane-producing organisms that slow transit.[3] When straining and incomplete emptying dominate, pelvic floor dysfunction is a likely driver, and pelvic floor biofeedback can help.[1]

Go deeper: https://www.drdanwool.com/blog/hypothyroidconstipation and https://www.drdanwool.com/blog/constipationandstress

7. Worse after hard workouts or stressful days

In my practice, bloating that spikes after intense training or a high-pressure week usually reflects the gut-brain connection. Stress hormones and overtraining slow motility and sharpen gut sensitivity.

Go deeper: https://www.drdanwool.com/blog/stress-gut-motility-bloating and https://www.drdanwool.com/blog/hiit-over-exercise-constipation-bloating

8. Bloating with reflux or constant burping 

Belching comes in two forms. Gastric belching releases air from the stomach and often travels with reflux. Supragastric belching pulls air into the esophagus and pushes it back out, and it is often tied to anxiety.[1] H. pylori and long-term acid suppression also belong on this list.

Go deeper: https://www.drdanwool.com/blog/burping and https://www.drdanwool.com/blog/h-pylori-guide

When Bloating Comes From Histamine

Histamine reaches your gut from three places: the food you eat, the bacteria living in your intestines, and your own immune cells.

Diamine oxidase (DAO) is the main enzyme in the gut lining that breaks down histamine from food.[8] DAO is most concentrated in the small intestine, which makes that stretch of gut your main line of defense against histamine from food.[8]

It's also where bacterial overgrowth does the most damage. When bacteria overgrow there, they add histamine at the same spot where your body is working to clear it. When the incoming load outpaces DAO, histamine builds up, and bloating is often the first sign.[6]

Here is how I investigate it:

  • The history comes first. I look for flushing, headaches, nasal congestion, itching, a racing heart, or loose stools within an hour or two of aged cheese, wine, cured meats, fermented foods, spinach, avocado, or leftovers. Leftovers matter because histamine rises as food sits. I also review every medication, since certain drugs and alcohol interfere with DAO.

  • Next comes a diet trial. Histamine intolerance has no validated biomarker, so diagnosis rests on clinical assessment and your response to a low-histamine diet followed by structured reintroduction.[9]

    Reviews treat a good response to that diet as the strongest confirmation available.[10] In my practice the trial runs 2-4 weeks, and we plan the reintroduction before we start. I treat the low-histamine diet as a diagnostic tool. Staying on it for months narrows your food choices without fixing the reason histamine is building up.

  • Then I add labs, with honest limits. Serum DAO measures the enzyme in your blood, which may not reflect activity in your gut lining, so I treat it as one data point.

    Stool testing adds something important. People with histamine intolerance carry more histamine-producing bacteria and fewer protective species, and that imbalance can raise gut histamine even when DAO levels are normal.[11]

  • Finally, I look upstream. SIBO, SIFO, dysbiosis, a leaky gut lining, and high estrogen all feed the histamine load, so the real treatment target is usually one of those. Research supports DAO enzyme supplements as an add-on to the diet.[10]

    In my practice I often recommend a DAO enzyme with meals for patients with this presentation during the trial, which is worth discussing with your practitioner.

The Hormone Connection

Bloating and hormones run in both directions.

In laboratory studies, estradiol at normal body concentrations activates mast cells and prompts them to release inflammatory mediators.[12]

Clinically, many of my female patients find their histamine symptoms and bloating peak in the weeks when estrogen runs highest. Falling progesterone before a period slows motility, and low thyroid function slows it all month long.

The gut also shapes your hormones. Your gut bacteria help recycle estrogen, and a disrupted microbiome can push estrogen levels in the wrong direction. I explain that loop in the master guide to gut health: https://drdanwool.com/blog/gut-health-what-it-is-and-how-it-breaks-down

Why Most Bloating Has Little to Do With Extra Gas

Most bloating remedies target gas. Activated charcoal, simethicone, and a shelf of probiotics all promise to reduce it. Yet many people with chronic bloating produce normal amounts of gas. Their gut wall is more sensitive, or their abdominal muscles react to a meal by pushing outward.

The research backs this up. Retraining the diaphragm and abdominal wall reduced distension in a controlled trial.[4] The AGA expert review points to visceral hypersensitivity as a treatment target and advises against using probiotics to treat bloating.[1] A probiotic can help when testing shows a specific gap. As a blanket fix for bloating, it rarely earns its cost.

How I Trace Bloating Back to Its Source

  • Step 1: Rule out what needs a scope or scan. Alarm signs go to conventional workup first. I coordinate with your gastroenterologist when that's already in progress.

  • Step 2: Map the pattern and test. The diet diary sorts you into one or more patterns, and testing confirms the driver. Breath, stool, blood, and hormone testing are ordered by pattern, never by default.

  • Step 3: Address the driver. That might mean treating SIBO, supporting stomach acid or enzyme output, running a histamine trial, correcting constipation, or rebalancing hormones. Research supports several herbal and pharmaceutical options for each, and the right one depends on your results, so they're worth discussing with your practitioner.

  • Step 4: Treat the mechanics. In my practice I often recommend diaphragmatic breathing and posture work for patients whose belly juts out after meals, pelvic floor therapy when emptying is the problem, and motility support to keep the small intestine clearing between meals.

  • Step 5: Rebuild. We expand your diet, reintroduce fiber slowly, restore the microbiome where testing shows gaps, and set up habits that prevent relapse.

Many patients notice a clear change within 4-6 weeks. When two or three patterns overlap, a full resolution usually takes 3-6months.

Bloating Article Directory

Every bloating article on the site, grouped by the pattern you recognize.

Start here

  • Bloating causes overview: https://www.drdanwool.com/blog/bloatingcauses

  • Gut health master guide: https://www.drdanwool.com/blog/gut-health-what-it-is-and-how-it-breaks-down

  • IBS hub guide: https://www.drdanwool.com/blog/what-is-ibs-why-standard-treatment-fails

Bloating right after meals

  • Functional dyspepsia: https://www.drdanwool.com/blog/functional-dyspepsia

  • Digestive enzymes guide: https://www.drdanwool.com/blog/digestive-enzyme-guide

  • Betaine HCl: https://www.drdanwool.com/blog/betaine-hcl

  • Digestive bitters: https://www.drdanwool.com/blog/digestive-bitters

  • Exocrine pancreatic insufficiency: https://www.drdanwool.com/blog/exocrine-pancreatic-insufficiency

  • GLP-1 medications and your gut: https://www.drdanwool.com/blog/glp1andguthealth

Bloating that builds through the day

  • SIBO guide: https://www.drdanwool.com/blog/siboguide

  • Migrating motor complex: https://www.drdanwool.com/blog/migrating-motor-complex-mmc

  • Abdominophrenic dyssynergia: https://www.drdanwool.com/blog/abdominophrenic-dysynergia-chronic-bloating

  • SIFO: https://www.drdanwool.com/blog/small-intestinal-fungal-overgrowth-sifo

  • At-home breath testing: https://www.drdanwool.com/blog/foodmarble-aire-breath-tester

Bloating from food choices

  • Bloating after vegetables and salads: https://www.drdanwool.com/blog/bloated-eating-vegetables-salad

  • Salads and gut health: https://www.drdanwool.com/blog/saladsbloatingandguthealth

  • Smoothies and protein drinks: https://www.drdanwool.com/blog/smoothies-protein-drinks-bloating

  • Gas and bloating when eating out: https://www.drdanwool.com/blog/gasbloatingeatingout

  • Low-FODMAP diet: https://www.drdanwool.com/blog/low-fodmap-diet

  • Fructose malabsorption: https://www.drdanwool.com/blog/fructose-malabsorption

  • Lactose and IBS: https://www.drdanwool.com/blog/lactoseandibs

  • Artificial sweeteners: https://www.drdanwool.com/blog/fakesugars

  • Fiber: https://www.drdanwool.com/blog/fiber

  • Alcohol and gut health: https://www.drdanwool.com/blog/alcohol-and-gut-health

  • Celiac disease: https://www.drdanwool.com/blog/celiac-disease

  • Non-celiac gluten sensitivity: https://www.drdanwool.com/blog/non-celiac-gluten-sensitivity

Bloating with histamine symptoms

  • DAO enzyme and histamine intolerance: https://www,drdanwool.com/blog/dao-enzyme-histamine-intolerance

  • Food sensitivity: https://www.drdanwool.com/blog/foodsensitivity2

  • Food sensitivity testing: https://www.drdanwool.com/blog/foodsensitivitytesting

  • Candida: https://www.drdanwool.com/blog/candida

Bloating after antibiotics

  • Antibiotics and gut health: https://www.drdanwool.com/blog/antibioticsandguthealth

  • Post-antibiotic dysbiosis: https://www.drdanwool.com/blog/post-antibiotic-dysbiosis-diarrhea

Bloating tied to hormones and medications

  • Hormonal bloating: https://www.drdanwool.com/blog/hormonal-bloating

  • Birth control and bloating: https://www.drdanwool.com/blog/birthcontrolandbloating

  • Spironolactone, constipation, and bloating: https://www.drdanwool.com/blog/spironolactone-constipation-bloating

  • Hypothyroidism and constipation: https://www.drdanwool.com/blog/hypothyroidconstipation

Bloating with constipation, stress, or exercise

  • Stress, gut motility, and bloating: https://www.drdanwool.com/blog/stress-gut-motility-bloating

  • Constipation and stress: https://www.drdanwool.com/blog/constipationandstress

  • Overtraining, constipation, and bloating: https://www.drdanwool.com/blog/hiit-over-exercise-constipation-bloating

  • Workouts and bloating: https://www.drdanwool.com/blog/workoutsandbloating

Bloating with reflux or burping

  • Burping and aerophagia: https://www.drdanwool.com/blog/burping

  • H. pylori guide: https://www.drdanwool.com/blog/h-pylori-guide

  • PPI guide: https://www.drdanwool.com/blog/ppiguide

  • Hiatal hernia: https://www.drdanwool.com/blog/hiatalhernia

Quick relief and remedies

  • Peppermint for gas relief: https://www.drdanwool.com/blog/peppermint-gut-health-gas-relief

  • Calcium carbonate tablets (Tums, etc.): https://www.drdanwool.com/blog/calcium-carbonate-antacid

  • Activated charcoal: https://drdanwool.com/blog/activated-charcoal

The Bottom Line on Bloating

Bloating that comes back every day is your gut reporting a specific problem, and the pattern tells you where to look. Map when it starts, what sets it off, and what travels with it, rule out the serious causes, and then test for the driver.

Lauren's map pointed to three overlapping causes: methane-producing overgrowth slowing her transit, a histamine load her smoothie and kombucha routine kept topping up, and a high-estrogen week that amplified both. Four months later, the pants she buttoned at 7 a.m. still fit at 9 p.m.

Related Reading

  • The Gut Health Master Guide: https://www.drdanwool.com/blog/gut-health-what-it-is-and-how-it-breaks-down

  • What IBS Actually Is and Why Standard Treatment Fails: https://www.drdanwool.com/blog/what-is-ibs-why-standard-treatment-fails

  • What Gut Dysbiosis Means and How to Test for It: https://www.drdanwool.com/blog/gut-dysbiosis-what-it-means-how-to-test

  • GERD and Acid Reflux: Why You're Still on Your PPI: https://www.drdanwool.com/blog/gerd-acid-reflux-guide

  • DAO Enzyme and Histamine Intolerance: https://www.drdanwool.com/blog/dao-enzyme-histamine-intolerance

Frequently Asked Questions about Bloating

Why am I bloated every day even when I eat healthy?

Quick Answer: "Healthy" foods like vegetables, salads, fiber, smoothies, and fermented foods are some of the most common bloating triggers.

Full Answer: Raw vegetables, beans, and many fruits are high in fermentable carbohydrates that feed gas-producing bacteria. Fermented foods and leftovers carry histamine. If you have bacterial overgrowth or trouble clearing histamine, a cleaner diet can make bloating worse. Tracking which foods trigger it helps sort out the cause.

Why does my stomach get bigger as the day goes on?

Quick Answer: Bloating that builds through the day usually points to fermentation stacking up with each meal, slow motility, or a muscle reflex that pushes the belly outward.

Full Answer: SIBO and slow small intestine clearing are common drivers. Abdominophrenic dysynergia is another, where the diaphragm drops and the abdominal wall relaxes after meals. Breath testing and a careful history help tell them apart.

Can histamine cause bloating?

Quick Answer: Yes. In patients with histamine intolerance, bloating is the most common and most severe symptom.

Full Answer: When histamine from food and gut bacteria outpaces the DAO enzyme, it builds up and irritates the gut. Look for bloating with flushing, headaches, congestion, or itching after wine, aged cheese, fermented foods, or leftovers. A short low-histamine trial with planned reintroduction is the most useful way to test the connection, ideally with your practitioner's guidance.

Is bloating before my period normal?

Quick Answer: It's common, and it can still be worth investigating when it disrupts your life.

Full Answer: Most healthy women report some bloating around their period. Shifting estrogen and progesterone change motility, fluid balance, and histamine handling. When cyclical bloating is severe or comes with heavy histamine symptoms, I look at hormone balance and gut health together.

When should I worry about bloating?

Quick Answer: See a doctor promptly for bloating with blood in your stool, weight loss, anemia, fever, vomiting, or a belly that keeps growing.

Full Answer: New, persistent bloating with early fullness or pelvic pain in women over 50 also needs prompt evaluation. These signs call for a conventional workup, including imaging or endoscopy, before any root-cause approach begins.

Do probiotics help with bloating?

Quick Answer: Usually not as a general fix. The AGA expert review advises against using probiotics to treat bloating.

Full Answer: Some people bloat more on probiotics, especially with SIBO or a histamine problem, since certain strains produce histamine. I use them when stool testing shows a specific gap, and I choose the strain to fit the finding.

What test should I ask for if I'm always bloated?

Quick Answer: A hydrogen and methane breath test (for SIBO) is a strong starting point, along with celiac disease screening if you haven't had it.

Full Answer: Depending on your pattern, stool testing, a thyroid panel, ferritin, serum DAO, tryptase, or cycle-timed hormone testing may follow. The right order depends on when your bloating starts and what comes with it, so bring your symptom diary to the conversation with your practitioner.

References

1. Moshiree B, Drossman D, Shaukat A. AGA Clinical Practice Update on evaluation and management of belching, abdominal bloating, and distention: expert review. Gastroenterology. 2023;165(3):791-800.e3. doi:10.1053/j.gastro.2023.04.039. https://doi.org/10.1053/j.gastro.2023.04.039

2. Ballou S, Singh P, Nee J, et al. Prevalence and associated factors of bloating: results from the Rome Foundation Global Epidemiology Study. Gastroenterology. 2023;165(3):647-655.e4. https://pmc.ncbi.nlm.nih.gov/articles/PMC10527500/

3. Rezaie A, Buresi M, Lembo A, et al. Hydrogen and methane-based breath testing in gastrointestinal disorders: the North American Consensus. Am J Gastroenterol. 2017;112(5):775-784. doi:10.1038/ajg.2017.46. https://pubmed.ncbi.nlm.nih.gov/28323273/

4. Barba E, Accarino A, Azpiroz F. Correction of abdominal distention by biofeedback-guided control of abdominothoracic muscular activity in a randomized, placebo-controlled trial. Clin Gastroenterol Hepatol. 2017;15(12):1922-1929. doi:10.1016/j.cgh.2017.06.052. https://pubmed.ncbi.nlm.nih.gov/28705783/

5. Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology. 2014;146(1):67-75.e5. doi:10.1053/j.gastro.2013.09.046. https://doi.org/10.1053/j.gastro.2013.09.046

6. Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019;17(3):427-433. doi:10.5217/ir.2018.00152. https://pubmed.ncbi.nlm.nih.gov/30836736/

7. Bernstein MT, Graff LA, Avery L, Palatnick C, Parnerowski K, Targownik LE. Gastrointestinal symptoms before and during menses in healthy women. BMC Womens Health. 2014;14:14. doi:10.1186/1472-6874-14-14. https://pubmed.ncbi.nlm.nih.gov/24450290/

8. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, Latorre-Moratalla M, Vidal-Carou MDC. Histamine intolerance: the current state of the art. Biomolecules. 2020;10(8):1181. doi:10.3390/biom10081181. https://pubmed.ncbi.nlm.nih.gov/32824107/

9. Jackson K, Busse W, Gálvez-Martín P, Terradillos A, Martínez-Puig D. Evidence for dietary management of histamine intolerance. Int J Mol Sci. 2025;26(18):9198. https://pmc.ncbi.nlm.nih.gov/articles/PMC12470264/

10. Hrubisko M, Danis R, Huorka M, Wawruch M. Histamine intolerance: the more we know the less we know. A review. Nutrients. 2021;13(7):2228. doi:10.3390/nu13072228. https://pubmed.ncbi.nlm.nih.gov/34209583/

11. Sánchez-Pérez S, Comas-Basté O, Duelo A, et al. Intestinal dysbiosis in patients with histamine intolerance. Nutrients. 2022;14(9):1774. doi:10.3390/nu14091774. https://doi.org/10.3390/nu14091774

12. Zaitsu M, Narita S, Lambert KC, et al. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol. 2007;44(8):1977-1985. https://pmc.ncbi.nlm.nih.gov/articles/PMC2603032/

Fix Your Gut, Solve Your Health

Dr. Wool's Gut Repair Plan starts with extended visits, specialty testing conventional workups rarely include, and a treatment plan built around root cause rather than symptom management. See if we're a fit → Book a 15-minute call with Dr. Wool. No cost, no obligation.

Get Started

Disclaimer: The information provided on this page is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Dr. Dan Wool nor his affiliates do not make claims about the effectiveness of supplements, peptides, hormones or other therapies outside of the contexts supported by cited clinical evidence and regulatory approval. Always consult a qualified healthcare provider before starting, changing, or stopping any medical or wellness program.

Share

Related Posts

Woman in a home kitchen pouring a white supplement powder from a container into a cup, with other supplement bottles on counter.

The Gut Supplements Worth Taking, Matched to Your Symptoms

Evidence-based gut supplement choices matched to common symptoms like IBS cramping, reflux, constipation, and antibiotic-related digestive upset.

Person pouring powdered L-glutamine from a small plastic scoop into clear measuring cup among nutritional supplement bottles and containers on a reflective countertop.

What Causes Leaky Gut and Why Zonulin Tests Mislead

Learn what causes increased intestinal permeability, why zonulin tests can mislead, and which drivers matter most when treating leaky gut.

Woman in orange blouse drinking probiotic kefir from a white plastic bottle, eyes closed, indoors with soft blurred background.

What Gut Dysbiosis Means and How to Test for It

Gut dysbiosis means your microbiome has shifted in a way that affects digestion and overall health. Learn the signs and how stool testing can help.

Author

Dr Dan Wool, NMD
Author
Dr Dan Wool, NMD

Dr. Dan Wool, NMD is a naturopathic gastroenterologist practicing in Scottsdale, Arizona. He specializes in gut health, hormone optimization, and men's health. He treats the conditions that fall between the cracks of standard care such as IBS, SIBO, acid reflux, leaky gut, low testosterone, thyroid disorders, hormonal imbalance, and fatigue that nobody has been able to explain. Read full bio

Top Categories

Gut Health130Health16Acid Reflux13Men's Health11Peptides11Ibs10Q&A7Bloating6Nutrition5Sibo5

CONTACT DR. WOOL

Office Location

9700 N 91st St Suite A-115

Scottsdale, AZ 85258

Serving Scottsdale, Paradise Valley, Phoenix, Cave Creek, Carefree, McCormick Ranch, Gainey Ranch, Doubletree Ranch, Fountain Hills, Desert Ridge, Mesa, Tempe, Chandler, Gilbert, Anthem, Surprise, Peoria

Phone 

(480) 741-2200

Email

dan@drdanwool.com

Hours

Mon., Wed., Thurs. 8:00am - 5:00pm AZ

Tue., Fri. Closed

Sat.-Sun. Closed

Average 5/5 rating from 80+ reviews

QUICK LINKS

About


Pricing


FAQ


Testimonials


Blog/Articles


Videos


Contact


Book Consult

POPULAR CONDITIONS

Acid Reflux


IBS


SIBO/IMO


Bloating


Men's Health


View All Conditions→

Medical Disclaimer: The information provided above is for educational purposes only and is not intended as medical advice. Diagnosis and treatment should be supervised by a qualified medical healthcare provider. Dr. Dan Wool is a licensed Naturopathic Medical Doctor (NMD) in the State of Arizona (License #18-1721). 


Page last medically reviewed: October 2026 by Dr. Dan Wool, NMD

©2026 Practical Vitality PLLC. All Rights Reserved  | Legal | Privacy Policy | Terms of Service | Accessibility | HIPAA Notice | Medical Disclaimer